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KMID : 0381219730050110564
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Journal of RIMSK
1973 Volume.5 No. 11 p.564 ~ p.570
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THE PARATHYROID AND CALCIUM METABOLISM
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Abstract
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The role of the parathyroids in cacium mtaebolism is well known. Parathormone acts directly on bone as well as on kidney and intestine for the homeostatic maintenance of plasma cacium level. In primary hyperpara-thyroidism, bone absorption is increased, thereby effecting a release of the stored mineral. When resorption is extensive and of long duration, the density of the skeleton decreases sufficiently to be evident in radiographs. It has been found that a large number of patients with hyperparathyroidism have abnormalities of bane.
The abnormalities frequently are not detectible by radiographic techniques, although they are manifest in microradiographic analyses of biopsy samples.
The most common cause of hyperparathyroidism is damage to or removal of, the parathyroid glands in the course of an operation on the thyroid gland. When the glands or their blood vessels have been merely damaged and not removed, there frequently is regeneration of tissure so that the clinical manifestations disappear in a few months. Dem age to the parathyroid glands following hemorrhage, infection, or thyroid gland irradiation (x-ray or radioiodine) is very rare.
Pseudohypoparathyroidism is interesting but rare syndrome was first discribed by Albright, Burnett, Smith and Parson. Patients with this syndrome have the same symptomatology, clinical findings, and physical signs as those with hypoparathyroidism, but, instead of locking the parathyroid hormone, they have an inability to respond to it. In addition, they have certain developmental abnormalities which are of theoretical interest and of aid in establishing the diagnosis.
Parathyroid glands is concerned to a large degree with a consideration of calcium and phosphate metabolism, In turn, the metabolism of calcium and phosphate is intinately related to the metabolism of the calcified tissues of the body, primarily bone. Hence, before the parathyroid glands are considred, current knowledge concerning the metabolism of calcium and phosphate of bone.
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